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http://repository.aaup.edu/jspui/handle/123456789/138
Title: | Molecular Investigation of Clinically Suspected Familial Mediterranean Fever Patients Using ARMS-PCR |
Authors: | khaled i qabaha phd |
Issue Date: | 2013 |
Publisher: | Malaria Chemotherapy, Control & Elimination |
Abstract: | Objective: To investigate the distribution of three most common missense mutations-M680I, M694V and V726A in pyrin gene among clinically suspected Familial Mediterranean Fever (FMF) patients of northern side of the West Bank/ Palestine. Methods: Fifty one blood samples were collected from clinically suspected FMF patients from Jenin, Nablus and RamAllah governorates and evaluated for the missense mutation in pyrin gene using ARMS-PCR technique. Results: Among fifty one patients that were evaluated, 31(60.8%) were identified with the mutations M694V, V726A and M680I in descending order of their occurrences. The results of the other 20 were undetermined. Conclusion: Molecular diagnosis of FMF through simple ARMS-PCR method helps to confirm the clinical diagnosis of the disease that relies on signs, symptoms, ethnicity and family history and response to colchicines. |
URI: | http://repository.aaup.edu/jspui/handle/123456789/138 |
Appears in Collections: | Faculty & Staff Scientific Research publications |
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