Recent progress in synthesizing Sulfonohydrazide Schiff bases (SHSBs) and their biological applications

Abstract

: In recent decades, numerous innovative methods for synthesis of Sulfonylhydrazide Schiff bases (SHSBs) have emerged. SHSBs ligands and their complexes possess numerous medical and industrial applications. Historically, scientists concentrated on creating poly-dentate SHSBs that incorporate many electron-donor elements such as oxygen, sulfur, nitrogen, and phosphorus because of their coordination properties with metal ion centers. The coordination mode verified the structural properties of their desired complexes, which enhanced in general the antioxidant, anticancer, anti-inflammatory, and antimicrobial properties for the complexes better than the free SHSBs ligands. Despite the fact that there have been very few published reviews and articles in SHSBs compared to the other Schiff bases. For instance, SHSBs were discussed in a review article in 2011; nevertheless, for reasons that remain unclear, subsequent reviews on this topic have been overlooked, prompting us to consider this minireview. Herein, in this work, we have illustrated the main significant synthesis of SHSBs ligands during the past five years. This contribution aggregated the latest synthesis methodologies for SHSBs to accelerate and improve researchers' endeavors in this important field. Moreover, the work has briefly addressed the biological applications of several SHSB compounds.