The short-term effect of Blood Flow Restriction walk training on insulin resistance and aerobic capacity on people with type2 diabetes mellitus – randomized feasibility trial رسالة ماجستير

Abstract

Background: Exercise intervention combined with blood-flow restriction (BFR) is comprehended to induce significant health improvement with less effort and time than the traditional exercises, this method of training is increasingly used with both healthy and unhealthy individuals . Insulin resistance which called pre diabetes condition, is a pathogenic driver of many modern diseases such as T2DM which are in origin due to the sedentary lifestyle. It is well known now that 75 - 150 minutes per week of moderate to high intensity exercise therapy is a major and safe component of the management program for type 2 diabetes. Exercising with moderate to high intensity 2 - 4 times/week could be a big challenge for diabetes population, health and time wise. Performing a low intensity BFR exercises can produce the same result as moderate - high intensity exercises among both healthy and unhealthy individuals. BFRT have been investigated among several cases, and showed a safe, interested and positive results. But to our knowledge, it is still not clearly evident with type 2 diabetes. Objectives: This study aims to investigate the acceptability and feasibility of BFR walk training intervention to adult with T2D. And to study the effects of walk training with BFR on aerobic capacity and insulin sensitivity on people with type 2 diabetes. Design: This study is a randomized feasibility study for a larger randomized controlled trial Methods: A total of 30 male participants, aged 40-65 years, took part in this trial. Participants were randomized to one of two groups; the first group received BFRT with aerobic exercise, and the second one received aerobic exercise alone. The intervention V programme consisted of 2 sessions per week for a period of 4 weeks. The outcomes measures were aerobic capacity by VO2Max, 6-minute walk test (6MWT), insulin resistance by HOMA score and physical function SF-36 scale. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS), version 21, with statistical significance set at P < 0.05. Results: Significant improvements between baseline and discharge scores were seen in both groups. However, there was a significant improvement in insulin resistance and aerobic capacity in favor of the BFRT group (P>0.05). Conclusion: This study shows that AE with BFRT was more effective in the management of IR and AC than AE alone in individuals with T2D.