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http://repository.aaup.edu/jspui/handle/123456789/637
Title: | Sequential-injection stripping analysis of nifuroxime using DNA-modified glassy carbon electrodes |
Authors: | nizam diab ali abuzuhri wolfgang schuhmann, $Other$Other |
Issue Date: | 2003 |
Publisher: | Biolectrochemistry |
Abstract: | The voltammetric behavior of nifuroxime was investigated comparing stationary voltammetric methods with the recently proposed sequential-injection stripping analysis (SISA), by using cyclic voltammetry (CV) and differential-pulse voltammetry at bare and DNA-modified glassy carbon (GC) electrodes. In cyclic voltammetry, reduction of nifuroxime at DNA-modified electrodes gives rise to a well-defined peak, and in contrast to bare GC surfaces, a re-oxidation peak could be observed. Optimization of the pre-concentration process at the DNA-modified surface led to a significant enhancement of the voltammetric current response, a better defined peak shape and an improved dynamic range. Based on this optimized voltammetric procedure, SISA has been evaluated for the determination of nifuroxime. The flow-system significantly facilitates the regeneration of the DNA-modified electrode surface, hence diminishing problems related to accumulation and memory effects. The linear detection range could be extended to 65 microM with a detection limit (3 s) of 0.68 microM, which corresponds to an absolute amount of 21 ng nifuroxime. |
URI: | http://repository.aaup.edu/jspui/handle/123456789/637 |
Appears in Collections: | Faculty & Staff Scientific Research publications |
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