The Association of Using Cooling Therapy Post Asphyxia among Newborns in NICU at Palestinian Hospitals: A Retrospective Study رسالة ماجستير

Abstract

Background: Perinatal hypoxia produces hypoxic-ischaemic encephalopathy (HIE), a primary lead to neonatal complications. Long-period neurological sequelae occur in one to two instances per 1,000 live term-born infants in affluent nations. Research suggests that starting whole-body moderate hypothermia (33-34°C) within six hours of delivery reduces mortality and neurodevelopmental impairment at 18 months and beyond. Hypothermia is most helpful when initiated during the latent phase of HIE before secondary energy failure leads to cell death (preclinical and clinical investigations confirm this). Purpose: To investigate the impact of using cooling therapy for neonatal post-asphyxia in the NICU at Privet Hospitals in West Bank. Methods: A retrospective, descriptive, quantitative study design was conducted, was conducted in the NICU Department at Privet Hospitals which contains a Neonate Intensive Care Unit. The target population was Newborns with Asphyxia and using cooling therapy, who met the inclusion criteria. A convincing sample was composed of 45 patients. Results: The gender distribution was nearly equal between male (51.1%) and female (48.9%) infants. Major adverse events were hypotension (26.7%), abnormal renal function (4.4%), and metabolic acidosis (22.2%). Death occurred in 4.9% of patients during the 72-hour intervention and 4.7% during the hospitalization. Primary results showed that 71.1% had no intermediate disability, 82.2% had no severe disability, and 91.1% survived. Significant connections were found, with gestational age inversely related to death (p=0.005) and blood gas indicators having variable associations. Chi-square testing found a significant correlation v (p<0.05) between 5-minute Apgar ratings, severe encephalopathy, adverse events during intervention and hospitalization, and mortality. Conclusion: The study's conclusion provides a thorough understanding of prenatal therapies and their effects on mother and newborn health outcomes. The study sheds light on the varied nature of neonatal care and the obstacles that come with dealing with prenatal insults by meticulously analyzing maternal and neonatal features, major adverse events, postnatal issues, and primary outcomes