Please use this identifier to cite or link to this item:
http://repository.aaup.edu/jspui/handle/123456789/2603
Title: | Evaluating Diagnostic Precision of Non-Enhanced MRA in Peripheral Arterial Disease رسالة ماجستير |
Authors: | Abbadi, Shatha Jamal$AAUP$Palestinian |
Keywords: | diagnostic,diseases,cardiovascular disorders,mra |
Issue Date: | 2024 |
Publisher: | AAUP |
Abstract: | In the dynamic landscape of vascular pathology, the early detection of Peripheral Arterial Occlusive Disease (PAOD) plays a crucial role in mitigating substantial morbidity. This study explores the pivotal role of Magnetic Resonance Angiography (MRA) in diagnosing cardiovascular disorders, specifically focusing on the enigmatic realm of peripheral arterial disease (PAD). Non-contrast MRA techniques, including QISS, 3D-FSE, and VS-MRA, have recently gained prominence in PAD imaging, surpassing traditional methods like TOF and PC-MRA. These advanced techniques offer superior fidelity, outperforming other diagnostic methods such as CTA and digital subtraction angiography. Non-contrast MRA proves particularly valuable for patients with compromised kidney function, pregnant individuals, those with elevated creatinine levels, and individuals with allergic reactions to gadolinium-based contrast agents, ensuring safety in diagnosis. The study's core objective is to achieve precise and secure diagnoses of PAOD when contrast media (CM) can’t be used. Specifically, the research assesses the effectiveness of ECG-triggered 3D-FSE MRA (Inhance-Deltaflow) in evaluating lower limb peripheral arterial disease. Utilizing a quantitative, observational, and cross-sectional approach, the study compares the diagnostic precision of non-contrast-enhanced angiography to contrast-enhanced MRA. The research employed the GE Optima 360, a 1.5 T MRI scanner, and an external ECG signal acquisition system (Magnitude 3200 from the USA) for signal enhancement. Images from 20 patients, 16 males and 4 females, were evaluated by two blinded radiologists, and graded on a scale from 0 to 5. The results demonstrate exceptional sensitivity, with a rate of 98.28% in region 1 (aortoiliac), 100.00% in VII region 2 (femoral), and 99.07% in region 3 (leg). The specificity remains unwavering at 100.00% across all regions, underscoring the test's precision in both diagnosis and exclusion. In summary, this study illuminates the potential of non-enhanced MRA in the realm of PAD diagnosis. By offering a safe and effective alternative for patients at risk due to contrast media, non-enhanced MRA emerges as a beacon of hope. This non-invasive approach, free from the need for contrast agents, not only ensures patient safety but also paves the way for diagnostic enlightenment in the field of vascular pathology |
Description: | Master Degree in CT and MRI Sciences |
URI: | http://repository.aaup.edu/jspui/handle/123456789/2603 |
Appears in Collections: | Master Theses and Ph.D. Dissertations |
Files in This Item:
File | Description | Size | Format | |
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شذى عبادي.pdf | 1.94 MB | Adobe PDF | View/Open |
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