Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS) among Elderly People in the Northern Districts of the West Bank Palestine. رسالة ماجستير

Abstract

Background: A plasma cell condition called monoclonal gammopathy of unknown significance (MGUS) is a precursor to multiple myeloma (MM) and other associated cancers. The frequency of MGUS has been thoroughly investigated in populations in the West and Asia, but there is still a dearth of information from the Middle East, especially Palestine(Han et al., 2020; Kyle et al., 2006). Objectives: The purpose of this study was to ascertain the incidence of MGUS in the older population in the northern West Bank areas of Palestine, as well as to pinpoint possible clinical and demographic risk factors linked to its development. Methods: 201 people who were 60 years of age or older participated in a cross-sectional study. The Cobas C8000 Roche analyzer was used to measure the total protein concentration. The Sebia Hydrasys 2 system was then used for serum protein electrophoresis (SPE). For confirmation, participants with aberrant gamma region results underwent immunofixation electrophoresis (IFE). Microsoft Excel and Python were used to perform statistical analysis. To evaluate relationships between MGUS and possible risk variables, the analyses used binary logistic regression, chi-square tests, and Mann-Whitney U tests. A 0.05 level of significance was used. Results: The prevalence of MGUS was 5.97 %overall, and it was considerably greater in men than in women (p = 0.0466). With age, the prevalence rose, reaching a peak of 9.09% in people V between the ages of 80 and 89. MGUS was shown to be most strongly associated with anemia or leukemia (p = 0.0007). The prevalence of MGUS did not differ significantly between provinces. Conclusions: The prevalence of MGUS in the West Bank's senior population is somewhat greater than certain international reports, although it is consistent with global trends (Kyle et al., 2006; Kristinsson et al., 2011). The study emphasizes the value of routine screening, especially for high-risk populations including older men and people with hematological disorders. To improve the early detection and management of MGUS in Palestine, it is advised to create focused screening programs and upgrade diagnostic infrastructure.