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dc.contributor.authorAl-Saheb, Rawan$Other$Palestinian-
dc.contributor.authorMakharza, Sami$Other$Palestinian-
dc.contributor.authorAbu Abed, Omar $Other$Palestinian-
dc.contributor.authorAl-battah, Feras $AAUP$Palestinian-
dc.description.abstractChalcones and their derivatives are becoming increasingly popular due to their various pharmacological effects. Chalcone molecules may be extracted from natural resources, entirely synthesised, or biosynthesised by modifying the natural ones. In the present study, five pyrazole-based adamantyl heterocyclic compounds were synthesised by condensation of 1-adamantyl chalcone with substituted phenylhydrazine. The products were characterised by using 1H NMR, 13C NMR and FT-IR spectroscopy. The microbiological activity of these compounds was investigated against bacteria and fungi. The new compounds showed good to moderate activity against the microbial species used for screening. All developed molecules showed antibacterial activity against Gram-negative and Gram-positive. These molecules showed antifungal activities against Fusarium oxysporum fungus and in a dose-dependent manner, apart from RS-1 molecules which showed compromised antifungal activity and even at a high dose.en_US
dc.publisherBioscience Reportsen_US
dc.subjectadamantyl chalconeen_US
dc.subjectantibacterial activityen_US
dc.titleSynthesis of new pyrazolone and pyrazole-based adamantyl chalcones and antimicrobial activityen_US
Appears in Collections:Faculty & Staff Scientific Research publications

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