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Title: Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets
Authors: El Omari, Nasreddine $Other$Other
Bakha, Mohamed $Other$Other
Imtara, Hamada$AAUP$Palestinian
Guaouguaoua, Fatima-Ezzahrae $Other$Other
Balahbib, Abdelaali $Other$Other
Zengin, Gokhan $Other$Other
Bouyahya, Abdelhakim $Other$Other
Keywords: Epigenetic, Cancer
Issue Date: 26-Jul-2021
Publisher: Environmental Science and Pollution Research
Citation: El Omari, N., Bakha, M., Imtara, H. et al. Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets. Environ Sci Pollut Res 28, 47869–47903 (2021).
Abstract: It has recently been proven that epigenetic dysregulation is importantly involved in cell transformation and therefore induces cancerous diseases. The development of molecules called epidrugs, which target specifically different epigenetic modifications to restore cellular memory and therefore the treatment, became a real challenge currently. Currently, bioactive compounds of medicinal plants as epidrugs have been can identified and explored in cancer therapy. Indeed, these molecules can target specifically different epigenetic modulators including DNMT, HDAC, HAT, and HMT. Moreover, some compounds exhibit stochastic epigenetic actions on different pathways regulating cell memory. In this work, pharmacodynamic actions of natural epidrugs belonging to cannabinoids, carotenoids, chalcones, fatty acids, lignans, polysaccharides, saponins, secoiridoids, steroids, tannins, tanshinones, and other chemical classes we reported and highlighted. In this review, the effects of several natural bioactive compounds of epigenetic medications on cancerous diseases were highlighted. Numerous active molecules belonging to different chemical classes such as cannabinoids, carotenoids, fatty acids, lignans, polysaccharides, saponins, secoiridoids, steroids, tannins, and tanshinones are discussed in this review.
ISSN: 09441344, 16147499
Appears in Collections:Faculty & Staff Scientific Research publications

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