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Title: Protective Effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on Gentamicin-Induced Nephrotoxicity: A Biochemical and Histological Analysis
Authors: Bouhrim, Mohamed $Other$Other
Bencheikh, Noureddine $Other$Other
Imtara, Hamada$AAUP$Palestinian
Daoudi, Nour Elhouda $Other$Other
Mechchate, Hamza $Other$Other
Ouassou, Hayat $Other$Other
Kharchoufa, Loubna $Other$Other
Elachouri, Mostafa$Other$Other
Mekhf, Hassane$Other$Other
Ziyyat, Abderrahim $Other$Other
Legssyer, Abdelkhaleq $Other$Other
Aziz, Mohammed $Other$Other
Bnouham, Mohamed $Other$Other
Issue Date: 31-Aug-2021
Publisher: The Scientific World Journal
Abstract: Opuntia dillenii is a medicinal plant with frequent usage in folk medicine to treat many illnesses. &e present study aims to investigate the protective effect of Opuntia dillenii seed oil against gentamicin-induced nephrotoxicity in rats. &e animals (rats) were randomly divided into three groups (i) the normal control group treated only with distilled water (10 mL/kg), (ii) the gentamicin group treated with distilled water (10 mL/kg) and received an intraperitoneal injection of gentamicin (80 mg/kg), and (iii) the group treated with the Opuntia dillenii seed oil (2 mL/kg) and also received an intraperitoneal injection of gentamicin (80 mg/kg). &e rats received their following treatments for 14 consecutive days orally. Serum urea, creatinine, gamma-glutamyl transferase, albumin, and electrolyte levels were quantified as the markers of acute renal and liver failure. Besides, the kidney and liver relative weight, kidney malondialdehydes, and kidney histological analysis were determined. &e results have shown that daily pretreatment with Opuntia dillenii seed oil (2 mL/kg) prevented severe alterations of biochemical parameters and disruptions of kidney tissue structures. In addition, the results of the present study showed for the first time that Opuntia dillenii seed oil reduced renal toxicity in gentamicin-induced nephrotoxicity in rats. &erefore, Opuntia dillenii seed oil may represent a new therapeutic avenue to preserve and protect renal function in gentamicin-treated patients.
ISSN: 1537744X, 23566140
Appears in Collections:Faculty & Staff Scientific Research publications

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