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Title: | Electrochemical Study on the Determination of Tinidazole in Tablets |
Authors: | ali z. abu zuhri suleiman al- khalil raqi shubeitah ibrahim el-hroub |
Keywords: | Tinidazole determinationDifferential-pulse polarographyPharmaceutical formulations |
Issue Date: | 1999 |
Publisher: | Journal of Pharmaceutical and Biomedical Analysis |
Abstract: | The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8–11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH<4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton–Robinson buffer of pH 3.0, which allows quantification over the range 0.03–7.30 ?g/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination. |
URI: | http://repository.aaup.edu/jspui/handle/123456789/736 |
Appears in Collections: | Faculty & Staff Scientific Research publications |
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