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Title: Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA
Authors: ibrahaim abu-shqair
nizam diab
radi salim
mohammad al-subu
Keywords: fluoroquinolone
DNA binding
UV - Visible Methods
Issue Date: 2013
Publisher: Asian Journal of Applied Sciences
Abstract: UV-visible spectroscopic methods were used to study the interaction of some fluoroquinolones with calf-thymus DNA. The binding constants of drug-DNA complexes were evaluated and the nature of binding of these drugs with DNA were elucidated. The results suggested that fluoroquinolones bind to DNA through an electrostatic mode of interaction with partial intercalation.
Appears in Collections:Faculty & Staff Scientific Research publications

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